The immediate-early 63 protein of Varicella-Zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo.

@article{Baiker2004TheI6,
  title={The immediate-early 63 protein of Varicella-Zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo.},
  author={Armin Baiker and Christoph P. Bagowski and Hideki Ito and Marvin H Sommer and Leigh Zerboni and Klaus Fabel and John Hay and William T. Ruyechan and Ann Margaret Arvin},
  journal={Journal of virology},
  year={2004},
  volume={78 3},
  pages={1181-94}
}
The immediate-early 63-kDa (IE63) protein of varicella-zoster virus (VZV) is a phosphoprotein encoded by open reading frame (ORF) ORF63/ORF70. To identify functional domains, 22 ORF63 mutations were evaluated for effects on IE63 binding to the major VZV transactivator, IE62, and on IE63 phosphorylation and nuclear localization in transient transfections… CONTINUE READING