The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection

Abstract

OBJECTIVES FTY720 modulates CD4+T cells by the augmentation of regulatory T cell activity, secretion of suppressive cytokines and suppression of IL-17 secretion by Th17 cells. To further understand the process of graft rejection/acceptance, we evaluated skin allograft survival and associated events after FTY720 treatment. METHODS F1 mice (C57BL/6xBALB/c… (More)

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Cite this paper

@inproceedings{Commodaro2012TheIB, title={The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection}, author={Alessandra Gonçalves Commodaro and Juliana Figueredo Pedregosa and Jean Pierre Schatzman Peron and Wesley Nogueira Brand{\~a}o and L. Rizzo and Valqu{\'i}ria Bueno}, booktitle={Clinics}, year={2012} }