The idiotypy of auto anti-allotype antibody induced in immunoglobulin allotype suppressed rabbits.

Rabbit anti-rabbit idiotype antibody was raised to both clonally heterogeneous and restricted auto anti-b6 antibodies induced in b6 allotype-suppressed (b6)/(b6) homozygous and b4/(b6) heterozygous rabbits. In every case the anti-idiotypic antibodies were specific only for the inducing antibody as shown by direct binding solid-phase RIA. Anti-idiotypes… CONTINUE READING