The idiotype (Id) cascade in mice elicited the production of anti-R24 Id and anti-anti-Id monoclonal antibodies with antitumor and protective activity against human melanoma.

@article{Ramos2011TheI,
  title={The idiotype (Id) cascade in mice elicited the production of anti-R24 Id and anti-anti-Id monoclonal antibodies with antitumor and protective activity against human melanoma.},
  author={Angelita S Ramos and Carolina Bellini Parise and Luiz R Travassos and Sang Won Han and Pedro Otavio de Campos-Lima and Jane Zveiter de Moraes},
  journal={Cancer science},
  year={2011},
  volume={102 1},
  pages={64-70}
}
Gangliosides have been considered as potential targets for immunotherapy because they are overexpressed on the surface of melanoma cells. However, immunization with purified gangliosides results in a very poor immune response, usually mediated by IgM antibodies. To overcome this limitation, we immunized mice with R24, a monoclonal antibody (mAb) that recognizes the most tumor-restricted ganglioside (GD3); our goal was to obtain anti-idiotype (Id) antibodies bearing the internal image of GD3… CONTINUE READING
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