The idic(X)(q13) in myeloid malignancies: breakpoint clustering in segmental duplications and association with TET2 mutations.

@article{Paulsson2010TheII,
  title={The idic(X)(q13) in myeloid malignancies: breakpoint clustering in segmental duplications and association with TET2 mutations.},
  author={Kajsa Paulsson and Claudia Haferlach and Christa Fonatsch and Anne M Hagemeijer and Mette Klarskov Andersen and Marilyn L. Slovak and Bertil Johansson},
  journal={Human molecular genetics},
  year={2010},
  volume={19 8},
  pages={1507-14}
}
Myelodysplastic syndromes and acute myeloid leukemia with an isodicentric X chromosome [idic(X)(q13)] occur in elderly women and frequently display ringed sideroblasts. Because of the rarity of idic(X)(q13), little is known about its formation, whether a fusion gene is generated, and patterns of additional aberrations. We here present an SNP array study of 14 idic(X)-positive myeloid malignancies, collected through an international collaborative effort. The breakpoints clustered in two regions… CONTINUE READING