The identification of the determinants of the cyclic, sequential binding of elongation factors tu and g to the ribosome.

@article{Yu2009TheIO,
  title={The identification of the determinants of the cyclic, sequential binding of elongation factors tu and g to the ribosome.},
  author={Huijun Yu and Y L Chan and Ira G. Wool},
  journal={Journal of molecular biology},
  year={2009},
  volume={386 3},
  pages={802-13}
}
Experiments dedicated to gaining an understanding of the mechanism underlying the orderly, sequential association of elongation factor Tu (EF-Tu) and elongation factor G (EF-G) with the ribosome during protein synthesis were undertaken. The binding of one EF is always followed by the binding of the other, despite the two sharing the same-or a largely overlapping-site and despite the two having isosteric structures. Aminoacyl-tRNA, peptidyl-tRNA, and deacylated-tRNA were bound in various… CONTINUE READING