The identification of polymerized and oxidized alpha-1 antitrypsins (ATs) induced by cigarette smoke as proinflammatory factors in the pathogenesis of emphysema

@inproceedings{Li2013TheIO,
  title={The identification of polymerized and oxidized alpha-1 antitrypsins (ATs) induced by cigarette smoke as proinflammatory factors in the pathogenesis of emphysema},
  author={Zhenjun Li and Susan Ossanna Wong},
  year={2013}
}
The molecular mechanisms that cause emphysema are complex but most theories suggest that an excess of proteinases is a crucial requirement. I find that the excess of neutrophils in Z alpha(1)-antitrypsin mutation individuals and the demonstration that polymers cause an influx of neutrophils when instilled into murine lungs. Polymers exert their effect… CONTINUE READING