The identification of nitric oxide as endothelium-derived relaxing factor.

@article{Loscalzo2013TheIO,
  title={The identification of nitric oxide as endothelium-derived relaxing factor.},
  author={Joseph Loscalzo},
  journal={Circulation research},
  year={2013},
  volume={113 2},
  pages={100-3}
}
The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines. The ubiquity of this natural product of cell metabolism and the complexity of its biochemistry provide a rich source of molecular mediators of phenotype in health and disease. 
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