The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein.

@article{He1998TheIO,
  title={The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein.},
  author={Xiangwei He and Nagao Hayashi and Nathan G. Walcott and Yoshinao Azuma and Thomas E. Patterson and F. Ralf Bischoff and Takeharu Nishimoto and Shelley Sazer},
  journal={Genetics},
  year={1998},
  volume={148 2},
  pages={645-56}
}
Perturbations of the spi1p GTPase system in fission yeast, caused by mutation or overexpression of several regulatory proteins, result in a unique terminal phenotype that includes condensed chromosomes, a wide medial septum, and a fragmented nuclear envelope. To identify potential regulators or targets of the spi1p GTPase system, a screen for cDNAs whose overexpression results in this terminal phenotype was conducted, and seven clones that represent three genes, named med1, med2, and med3… CONTINUE READING

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