The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily.

@article{Mazzocco2002TheIO,
  title={The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily.},
  author={Michela Mazzocco and Massimo Maffei and A. Egeo and Alessandro Vergano and P. Arrigo and Raffaella Di Lisi and Fabio Ghiotto and P. Scartezzini},
  journal={Gene},
  year={2002},
  volume={291 1-2},
  pages={233-9}
}
The SH3 binding glutamic acid-rich (SH3BGR) gene was cloned in an effort to identify genes located to human chromosome 21, within the congenital heart disease region, and expressed in the developing heart. After the identification of SH3BGR, two human homologous genes, SH3BGRL and SH3BGRL3, were identified and mapped to chromosome Xq13.3 and 1p34.3-35, respectively. SH3BGRL and SH3BGRL3 code for small proteins similar to the N-terminal region of the SH3BGR protein. SH3BGRL3 protein shows a… CONTINUE READING

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