The iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During Endocytosis

  title={The iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During Endocytosis},
  author={Sarah L Gordon and Michael A. Cousin},
  booktitle={Front. Synaptic Neurosci.},
The reformation of synaptic vesicles (SVs) during endocytosis is essential for the maintenance of neurotransmission in central nerve terminals. Newly formed SVs must be generated with the correct protein cargo in the correct stoichiometry to be functional for exocytosis. Classical clathrin adaptor protein complexes play a key role in sorting and clustering synaptic vesicle cargo in this regard. However it is becoming increasingly apparent that additional "fail-safe" mechanisms exist to ensure… CONTINUE READING
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AP180 and CALM

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