The hypoxic ventilatory response and TRPA1 antagonism in conscious mice.

  title={The hypoxic ventilatory response and TRPA1 antagonism in conscious mice.},
  author={Mieczysław Pokorski and Kotaro Takeda and Yukio Sato and Yasunobu Okada},
  journal={Acta physiologica},
  volume={210 4},
AIM Recently, TRPA1 channels, richly expressed in both peripheral and central neural systems, have been proposed as novel sensors of changes in oxygen concentration along the hypoxic-hyperoxic continuum. In this study, we investigated the hypothesis that TRPA1 channels blockade should profoundly affect the hypoxic ventilatory response (HVR). METHODS We examined the chemosensory ventilatory responses in conscious mice before and after intraperitoneal administration of the specific TRPA1… CONTINUE READING
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