The hypoxic tumour microenvironment and metastatic progression

@article{Subarsky2003TheHT,
  title={The hypoxic tumour microenvironment and metastatic progression},
  author={Patrick Subarsky and Richard Peter Hill},
  journal={Clinical & Experimental Metastasis},
  year={2003},
  volume={20},
  pages={237-250}
}
The microenvironment of solid tumours contains regions of poor oxygenation and high acidity. Growing evidence from clinical and experimental studies points to a fundamental role for hypoxia in metastatic progression. Prolonged hypoxia increases genomic instability, genomic heterogeneity, and may act as a selective pressure for tumour cell variants. Hypoxia can also act in an epigenetic fashion, altering the expression of genes. Hypoxia-induced changes in gene expression alter non-specific… CONTINUE READING

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