The hypoxic tumour microenvironment and metastatic progression

  title={The hypoxic tumour microenvironment and metastatic progression},
  author={Patrick Subarsky and Richard Peter Hill},
  journal={Clinical & Experimental Metastasis},
The microenvironment of solid tumours contains regions of poor oxygenation and high acidity. Growing evidence from clinical and experimental studies points to a fundamental role for hypoxia in metastatic progression. Prolonged hypoxia increases genomic instability, genomic heterogeneity, and may act as a selective pressure for tumour cell variants. Hypoxia can also act in an epigenetic fashion, altering the expression of genes. Hypoxia-induced changes in gene expression alter non-specific… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 135 references

Transcriptional response to hypoxia in human tumors.

Journal of the National Cancer Institute • 2001
View 10 Excerpts
Highly Influenced

Candidate genes for the hypoxic tumor phenotype.

Cancer research • 2000
View 10 Excerpts
Highly Influenced

Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2000
View 6 Excerpts
Highly Influenced

Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts

EK Rofstad, EF Halsor
Cancer Res • 2000
View 6 Excerpts
Highly Influenced

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