The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer

@article{Turner2002TheHG,
  title={The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer},
  author={Kevin J. Turner and Jeremy P. Crew and Charles C. Wykoff and Peter Hamilton Watson and Richard Poulsom and Jarom{\'i}r Pastorek and Peter J Ratcliffe and David W Cranston and A. L. Harris},
  journal={British Journal of Cancer},
  year={2002},
  volume={86},
  pages={1276 - 1282}
}
Regulation by hypoxia may underlie the expression of vascular endothelial growth factor in bladder cancer. We have compared the distribution of vascular endothelial growth factor mRNA with a hypoxia marker, carbonic anhydrase 9 (CA IX). vascular endothelial growth factor mRNA was analysed by in situ hybridisation and CA IX by immunochemistry in 22 cases of bladder cancer. The relationship of microvessels to the distribution of CA IX was determined. In a separate series of 49 superficial tumours… CONTINUE READING

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