The hypothesis of an ambient level of acetylcholine in the central nervous system.

@article{Descarries1998TheHO,
  title={The hypothesis of an ambient level of acetylcholine in the central nervous system.},
  author={Laurent Descarries},
  journal={Journal of physiology, Paris},
  year={1998},
  volume={92 3-4},
  pages={215-20}
}
Recent ultrastructural data demonstrate the largely asynaptic character of the cholinergic innervation in many regions of adult rat brain. These data favour the hypothesis of a diffuse transmission/modulation by acetylcholine in the CNS and, by way of consequence, that of a persistent, low level of acetylcholine in the extracellular space. 

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