The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor.

@article{Guscott2003TheHE,
  title={The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor.},
  author={Martin R Guscott and Elizabeth Egan and Graham P. Cook and Josephine A Stanton and Margaret S Beer and Thomas W. Rosahl and S. Hartmann and Janusz J. Kulagowski and G Mcallister and Kevin C. F. Fone and Peter H. Hutson},
  journal={Neuropharmacology},
  year={2003},
  volume={44 8},
  pages={1031-7}
}
The 5-HT(7) receptor is a recent addition to the 5-HT receptor family and to date there is no clear idea as to its potential role in the CNS. The receptor has been mapped by in situ hybridization and 5-HT(7)-like immunoreactivity and has been detected in discrete areas of the brain including the hypothalamus (Oliver et al., 1999). This suggests the receptor may be involved in temperature regulation and have shown that a selective 5-HT(7) receptor antagonist reverses the hypothermic effect of 5… CONTINUE READING

From This Paper

Topics from this paper.
34 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…