The hypothalamic-pituitary-adrenal axis and the female reproductive system.

@article{Magiakou1997TheHA,
  title={The hypothalamic-pituitary-adrenal axis and the female reproductive system.},
  author={Maria Alexandra Magiakou and George P Mastorakos and Elizabeth L. Webster and George P. Chrousos},
  journal={Annals of the New York Academy of Sciences},
  year={1997},
  volume={816},
  pages={42-56}
}
The hypothalamic-pituitary-adrenal (HPA) axis and the female reproductive system are intertwined and exhibit a complex relationship. Thus, the HPA axis exerts profound, mostly inhibitory effects, on the reproductive axis, with corticotropin-releasing hormone (CRH) and CRH-induced propiomelanocortin peptides inhibiting hypothalamic GnRH secretion, and with glucocorticoids inhibiting pituitary LH and ovarian estrogen and progesterone secretion and rendering estrogen-target tissues, such as the… CONTINUE READING