The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats.

@article{Wenger2002TheHL,
  title={The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats.},
  author={Tibor Wenger and Ida Gerendai and Filomena Fezza and Sara Gonzalez and Tiziana Bisogno and Javier Fern{\'a}ndez-Ruiz and Vincenzo Di Marzo},
  journal={Life sciences},
  year={2002},
  volume={70 12},
  pages={
          1407-14
        }
}
Several data suggest that the endogenous cannabinoid system plays a role in neuroendocrine regulation in adult individuals, although the information on its involvement in peri-pubertal processes is scarce. In the present study, we have examined the ontogeny (from postnatal day [PND] 5 up to adulthood) of hypothalamic and anterior pituitary contents of anandamide (arachidonyl-ethanolamide, AEA). We observed that the content of AEA in the hypothalamus was low at PND5, PND15 and PND25, but it… CONTINUE READING
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