The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats.

@article{Zhang2002TheHA,
  title={The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats.},
  author={Jian Zhang and Abdel A Abdel-Rahman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={303 1},
  pages={
          204-10
        }
}
Rilmenidine is a second-generation centrally acting antihypertensive drug that acts mainly through the activation of the imidazoline (I(1)) receptor in the rostral ventrolateral medulla (RVLM). To investigate the contribution of the N-methyl-D-aspartate receptor (NMDAR) to the hypotensive action of rilmenidine, experiments were undertaken in conscious male spontaneously hypertensive rats (SHRs). Microinjection of cumulative doses of rilmenidine (10, 20, and 40 nmol) at 10- to 15-min intervals… CONTINUE READING

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