The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors.

@article{Smart2000TheHA,
  title={The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors.},
  author={Darren Smart and Jeffrey C. Jerman and Stephen J. Brough and William A. Neville and Frances Jewitt and Rod A. Porter},
  journal={British journal of pharmacology},
  year={2000},
  volume={129 7},
  pages={
          1289-91
        }
}
The pharmacology of the orexin-like peptides, hypocretin-1 and hypocretin-2, was studied in Chinese hamster ovary (CHO) cells stably expressing orexin-1 (OX(1)) or orexin-2 (OX(2)) receptors by measuring intracellular calcium ([Ca(2+)](i)) using Fluo-3AM. Orexin-A and orexin-B increased [Ca(2+)](i) in CHO-OX(1) (pEC(50)=7. 99+/-0.05 and 7.00+/-0.10 respectively, n=8) and CHO-OX(2) (pEC(50)=8.30+/-0.05 and 8.21+/-0.07 respectively, n=5). However, hypocretin-1 and hypocretin-2 were markedly less… CONTINUE READING
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