The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

@article{Lecea1998TheHH,
  title={The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.},
  author={Luis de Lecea and Thomas S Kilduff and Christelle Peyron and Xiaolian Gao and Pamela E. Foye and Patria E. Danielson and Chiaki Fukuhara and Elena L. F. Battenberg and Vigdis T. Gautvik and Frederick Sheldon Bartlett and Wayne N. Frankel and Anthony N van den Pol and Floyd E. Bloom and Kaare M. Gautvik and J. Gregor Sutcliffe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 1},
  pages={
          322-7
        }
}
We describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin. The hypocretin (Hcrt) protein products are restricted to neuronal cell bodies of the dorsal and lateral hypothalamic areas. The fibers of these neurons are widespread throughout the posterior hypothalamus and project to multiple targets in other areas, including brainstem and thalamus. Hcrt… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 1,254 CITATIONS, ESTIMATED 33% COVERAGE

Orexins, Sleep, and Blood Pressure

  • Current hypertension reports
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases

  • Front. Mol. Neurosci.
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Orexin signaling is necessary for hypoglycemia-induced prevention of conditioned place preference.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2016
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

History of narcolepsy at Stanford University

  • Immunologic research
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice

  • Behavioural Brain Research
  • 2013
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Central functions of the orexinergic system

VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Recent progress in orexin/hypocretin physiology and pharmacology.

  • Biomolecular concepts
  • 2012
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1998
2019

CITATION STATISTICS

  • 66 Highly Influenced Citations

  • Averaged 76 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-4 OF 4 REFERENCES

de Lecea et al

W. C. Randall, ed. Nervous Control of Cardiovascular Function Oxford Press, +6 authors 0.5 mM GTP. 326 Neurobiology
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

de Lecea et al

L. de Lecea, E. Soriano, +5 authors 286–296. Neurobiology
  • Proc. Natl. Acad. Sci. USA 95
  • 1998
VIEW 2 EXCERPTS

Pharmacol

G. P. Smith, J. Gibbs
  • Biochem . Behav .
  • 1975

Similar Papers

Loading similar papers…