The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron.

@article{CarrisozaGaytn2011TheHC,
  title={The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron.},
  author={Rolando Carrisoza-Gayt{\'a}n and Claudia Rangel and Carolina Salvador and Ricardo Salda{\~n}a-Meyer and Christian Escalona and Lisa M. Satlin and Wen Bin Liu and Beth Zavilowitz and Joyce Trujillo and Norma A. Bobadilla and Laura I. Escobar},
  journal={Kidney international},
  year={2011},
  volume={80 8},
  pages={
          832-40
        }
}
Recent studies have identified Rhesus proteins as important molecules for ammonia transport in acid-secreting intercalated cells in the distal nephron. Here, we provide evidence for an additional molecule that can mediate NH3/NH4 excretion, the subtype 2 of the hyperpolarization-activated cyclic nucleotide-gated channel family (HCN2), in collecting ducts in rat renal cortex and medulla. Chronic metabolic acidosis in rats did not alter HCN2 protein expression but downregulated the relative… CONTINUE READING

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