The hyperphagic effect of 3α-hydroxylated pregnane steroids in male rats

@article{Chen1996TheHE,
  title={The hyperphagic effect of 3$\alpha$-hydroxylated pregnane steroids in male rats},
  author={Shu-Wen Chen and L. Rodriguez and M. Davies and G. Loew},
  journal={Pharmacology Biochemistry and Behavior},
  year={1996},
  volume={53},
  pages={777-782}
}
Like benzodiazepines receptor (BDZR) ligands, 3α-hydroxylated, 5α, or 5β pregnane steroids are sedative, anticonvulsant, and anxiolytic. BDZR ligands also modulate the feeding response. Therefore, in this study we have investigated the effects of four 3α-hydroxylated pregnane steroids — Pregnanolone (3α-hydroxy-5β-pregnan-20-one), allopregnanolone (3α-hydroxy-5α-pregnan-20-one), alphaxalone (3α-hydroxy-5α-pregnan-11,20-dione), and 5β-pregnanediol (5β-pregnan-3α,20α-diol) on food intake. In non… Expand
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