The hypermethylation and protein expression of p16 INK4A and DNA repair gene O 6 -methylguanine-DNA methyltransferase in various uterine cervical lesions

@article{Lin2004TheHA,
  title={The hypermethylation and protein expression of p16 INK4A and DNA repair gene O 6 -methylguanine-DNA methyltransferase in various uterine cervical lesions},
  author={Zhenhua Lin and Meihua Gao and Xianglan Zhang and Y. Kim and Eung-Seok Lee and Han-Kyeom Kim and Insun S Kim},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2004},
  volume={131},
  pages={364-370}
}
This study is aimed at investigating the significance of gene promoter methylation status and protein expression of p16 INK4A and O6-methylguanine-DNA methyltransferase (MGMT) in the various uterine cervical lesions. Methylation status by using methylation-specific polymerase chain reaction (MS-PCR) and protein expression by using immunohistochemistry for p16 INK4A and MGMT genes were performed in cervical squamous intraepithelial neoplasms (CIN), invasive squamous cell carcinomas (SCC… CONTINUE READING

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