The hyperleptinemia and ObRb expression in hyperphagic obese rats.

@article{Han2010TheHA,
  title={The hyperleptinemia and ObRb expression in hyperphagic obese rats.},
  author={Ying Han and Yeonsoo Joe and Eunhui Seo and Sa Rah Lee and M S Park and Hye-Jeong Lee and Duk Kyu Kim},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 1},
  pages={70-4}
}
Leptin resistance associated with hyperleptinemia in high-fat-diet-induced obese rats and aged obese rats is well established, but it is not clear whether hyperphagia-induced obese rats also develop leptin resistance. We investigated whether Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which are a strain of hyperphagia-induced obese rats, develop leptin resistance and whether caloric restriction reversed this leptin resistance-induced leptin receptor (ObRb) deficit. Twenty male OLETF rats… CONTINUE READING