The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.

@article{Lin2005TheHI,
  title={The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.},
  author={Ying Lin and Anders H. Berg and Puneeth Iyengar and Tony K. T. Lam and Adria Giacca and Terry P. Combs and Michael W. Rajala and Xin Du and Brent Rollman and Weijie Li and Meredith Hawkins and Nir Barzilai and Christopher J Rhodes and Ivan George Fantus and Michael Brownlee and Phillip E Scherer},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 6},
  pages={4617-26}
}
Hyperglycemia is a major independent risk factor for diabetic macrovascular disease. The consequences of exposure of endothelial cells to hyperglycemia are well established. However, little is known about how adipocytes respond to both acute as well as chronic exposure to physiological levels of hyperglycemia. Here, we analyze adipocytes exposed to hyperglycemia both in vitro as well as in vivo. Comparing cells differentiated at 4 mm to cells differentiated at 25 mm glucose (the standard… CONTINUE READING

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