The hypereosinophilic syndromes: still more heterogeneity.

  title={The hypereosinophilic syndromes: still more heterogeneity.},
  author={Gerald J. Gleich and Kristin M. Leiferman},
  journal={Current opinion in immunology},
  volume={17 6},
In 1968, the term hypereosinophilic syndromes (HES) was coined to refer to a spectrum of eosinophil-associated diseases presumed to be caused by an underlying immunological pathology. In the 1990s, the identification of an HES subset with T lymphocyte clonality and production of cytokines, particularly IL-5, validated this concept. Then, in 2002, imatinib mesylate, which was introduced for the treatment of chronic myelogenous leukemia, effectively controlled another subgroup of HES patients… CONTINUE READING


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