The hypercube structure of the genetic code explains conservative and non-conservative aminoacid substitutions in vivo and in vitro.


A representation of the genetic code as a six-dimensional Boolean hypercube is described. This structure is the result of the hierarchical order of the interaction energies of the bases in codon-anticodon recognition. In this paper it is applied to study molecular evolution in vivo and in vitro. In the first case we compared aligned positions in homologous… (More)


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