The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.

@article{Gustafsen2014TheHG,
  title={The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.},
  author={Camilla Gustafsen and Mads Kjolby and Mette Nyegaard and Manuel Mattheisen and Jesper Lundhede and Henriette N\orm\olle Buttensch\on and Ole Mors and Jacob Fog Bentzon and Peder Madsen and Anders Nykjaer and Simon Glerup},
  journal={Cell metabolism},
  year={2014},
  volume={19 2},
  pages={310-8}
}
Circulating PCSK9 destines low-density lipoprotein receptor for degradation in lysosomes, resulting in increased LDL cholesterol. Accordingly, it is an attractive drug target for hypercholesterolemia, and results from clinical trials are promising. While the physiological role of PCSK9 in cholesterol metabolism is well described, its complex mechanism of action remains poorly understood, although it is known to depend on intracellular trafficking. We here identify sortilin, encoded by the… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

The PCSK9 decade.

View 2 Excerpts
Highly Influenced

Sensors and regulators of intracellular pH

Nature Reviews Molecular Cell Biology • 2010
View 2 Excerpts
Highly Influenced

Genetic and metabolic determinants of plasma PCSK9 levels.

The Journal of clinical endocrinology and metabolism • 2009
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…