The hypercalcemic effect of parathyroid hormone and skeletal cyclic AMP.

@article{Nagata1975TheHE,
  title={The hypercalcemic effect of parathyroid hormone and skeletal cyclic AMP.},
  author={Nanae Nagata and Mutsuo Sasaki and Narimichi Kimura and Kunio Nakane},
  journal={Endocrinology},
  year={1975},
  volume={96 3},
  pages={725-31}
}
The effects of parathyroid hormone (PTH) on bone mineral mobilization are thought to involve the second messenger cyclic AMP. Intravenous administration of 10 U PTH induced rapid and marked accumulation of cyclic AMP in calvaria and plasma of thyroparathyroidectomized rats. The changes in cyclic AMP concentrations were not sustained, but returned to near-baseline values before the rise in plasma calcium concentration was manifest. Changes in the plasma levels of calcium and cyclic AMP in… CONTINUE READING

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