The hyperalgesic effects of prostacyclin and prostaglandin E2.

  title={The hyperalgesic effects of prostacyclin and prostaglandin E2.},
  author={S{\'e}rgio H. Ferreira and M. Nakamura and M S de Abreu Castro},
  volume={16 1},

Prostaglandin (PG) modulation of bradykinin-induced hyperalgesia and oedema in the guinea-pig paw--effects of PGD2, PGE2 and PGI2.

The relative potencies of PGD2, PGE2 and PGI2 in potentiating bradykinin-induced hyperalgesia and oedema were determined in the paws of aspirin-treated guinea-pigs and may reflect interspecies differences in modulation of inflammatory reactions by prostanoids.

Prostanoids in nociception and pain.

Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice.

Subcutaneous injection of formaldehyde into mouse hind paw elicited pain responses consisting of licking or biting of the paw, which were observed biphasically, and neurotropin was injected intraperitoneally 30 min prior to treatments, hyperalgesia was suppressed to the control level.



Prostaglandins, aspirin-like drugs and analgesia.

Compared the pain producing activity of fatty acid hydroperoxides with that of high concentrations of acetylcholine, bradykinin, histamine and PGE1 on intradermal injection in man, the intensity of the pain induced was greater than that induced by the other agonists but for all except P GE1 the pain was transitory.