The hygiene hypothesis in autoimmunity: the role of pathogens and commensals

@article{Bach2018TheHH,
  title={The hygiene hypothesis in autoimmunity: the role of pathogens and commensals},
  author={J. -F. Bach},
  journal={Nature Reviews Immunology},
  year={2018},
  volume={18},
  pages={105-120}
}
The incidence of autoimmune diseases has been steadily rising. Concomitantly, the incidence of most infectious diseases has declined. This observation gave rise to the hygiene hypothesis, which postulates that a reduction in the frequency of infections contributes directly to the increase in the frequency of autoimmune and allergic diseases. This hypothesis is supported by robust epidemiological data, but the underlying mechanisms are unclear. Pathogens are known to be important, as autoimmune… CONTINUE READING
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