The hygiene hypothesis and psychiatric disorders.

@article{Rook2008TheHH,
  title={The hygiene hypothesis and psychiatric disorders.},
  author={Graham Arthur William Rook and Christopher A Lowry},
  journal={Trends in immunology},
  year={2008},
  volume={29 4},
  pages={
          150-8
        }
}
The hygiene hypothesis proposes that several chronic inflammatory disorders (allergies, autoimmunity, inflammatory bowel disease) are increasing in prevalence in developed countries because a changing microbial environment has perturbed immunoregulatory circuits which normally terminate inflammatory responses. Some stress-related psychiatric disorders, particularly depression and anxiety, are associated with markers of ongoing inflammation, even without any accompanying inflammatory disorder… CONTINUE READING

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