The hydroxyl radical scavenger Nicaraven inhibits glutamate release after spinal injury in rats.

Abstract

Neuronal degeneration after trauma is mediated in part by release of excitatory amino acids (EAAs) and oxygen free radicals (OFR). We evaluated the effect of i.v. treatment with a hydroxyl radical scavenger ((+/-)-N,N'-propylenedinicotinamide; AVS) and spinal hypothermia (33 degrees C) on spinal CSF glutamate release after spinal trauma. In a control group… (More)

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Cite this paper

@article{Yamamoto1998TheHR, title={The hydroxyl radical scavenger Nicaraven inhibits glutamate release after spinal injury in rats.}, author={Kei Yamamoto and Takashi Ishikawa and Tomoya Sakabe and Tetsuya Taguchi and Shinichi Kawai and Martin Mar{\vs}ala}, journal={Neuroreport}, year={1998}, volume={9 7}, pages={1655-9} }