The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue.

@article{Hellberg2003TheHO,
  title={The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue.},
  author={Mark R. Hellberg and T L Ke and Karen S. Haggard and Peter G. Klimko and Tom R Dean and Gustav Graff},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  year={2003},
  volume={19 2},
  pages={
          97-103
        }
}
  • M. Hellberg, T. Ke, +3 authors G. Graff
  • Published 2003
  • Chemistry, Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Bimatoprost (Lumigan), the ethyl amide derivative of the potent prostaglandin FP agonist 17-phenyl-trinor PGF(2alpha), has been reported to be a member of a pharmacologically unique class of ocular hypotensive agents. To confirm that bimatoprost, which is intrinsically active as an FP prostaglandin agonist, is also a prostaglandin analog prodrug, the hydrolysis of bimatoprost by ocular tissues was studied by incubating solutions containing bimatoprost with either human or rabbit ocular tissue… Expand
Update and commentary on the pro-drug bimatoprost and a putative ‘prostamide receptor’
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An update on the discovery of potent and efficacious intraocular pressure (IOP)-lowering FP-class prostaglandin (PG) analogs is provided and published data is discussed that addresses the debate in this arena. Expand
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An improvement in the pharmacokinetic parameters of ISV-215 may provide a better platform to optimize a bimatoprost formulation that offers the same degree of efficacy in lowering intraocular pressure and improved therapeutic index in glaucomatous patients by lessening the ocular side effects associated with long-term use of topical prostaglandin F2α analogs. Expand
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