The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal

@inproceedings{Maiuri2013TheHN,
  title={The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal},
  author={Tamara Maiuri and T. Woloshansky and Jianrun Xia and Ray Truant},
  booktitle={Human molecular genetics},
  year={2013}
}
The first 17 amino acids of Huntington's disease (HD) protein, huntingtin, comprise an amphipathic alpha-helical domain that can target huntingtin to the endoplasmic reticulum (ER). N17 is phosphorylated at two serines, shown to be important for disease development in genetic mouse models, and shown to be modified by agents that reverse the disease phenotype in an HD mouse model. Here, we show that the hydrophobic face of N17 comprises a consensus CRM1/exportin-dependent nuclear export signal… CONTINUE READING

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