The hunting of the Src

@article{Martin2001TheHO,
  title={The hunting of the Src},
  author={G. Steven Martin},
  journal={Nature Reviews Molecular Cell Biology},
  year={2001},
  volume={2},
  pages={467-475}
}
  • G. Martin
  • Published 2001
  • Biology
  • Nature Reviews Molecular Cell Biology
The non-receptor tyrosine kinase Src is important for many aspects of cell physiology. The viral src gene was the first retroviral oncogene to be identified, and its cellular counterpart was the first proto-oncogene to be discovered in the vertebrate genome. Src has been important, not only as an object of study in itself, but also as an entry point into the molecular genetics of cancer. 

Inhibition of proto-oncogene c-Src tyrosine kinase: toward a new antiarrhythmic strategy?

6 Regulation of Tyrosine Kinase Signaling by Cbl in Hematopoietic Stem Cells

Findings in v-Src highlight the critical importance of precise regulation of TK activities in order to avoid detrimental consequences to the homeostasis of the organisms.

Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses

This paper focuses on the roles played by Src and other PTKs in cancer cell-specific behavior, that is, evasion of apoptosis or cell death under stressful extracellular and/or intracellular microenvironments (i.e., hypoxia, anoikis, hypoglycemia, and serum deprivation).

Retroviral oncogenes: a historical primer

Key features of all retroviral oncogenes were first identified in src, the oncogene of Rous sarcoma virus, including non-involvement in viral replication, coding for a single protein and cellular origin.

SRC in human carcinogenesis.

In a variety of tumor types including those derived from the colon and breast, the Src non-receptor tyrosine kinase is either overexpressed or constitutively active in a large percentage of the tumors.

Src in human carcinogenesis.

In a variety of tumor types including those derived from the colon and breast, the Src non-receptor tyrosine kinase is either overexpressed or constitutively active in a large percentage of the tumors.

Breakthroughs and Views Src protein – tyrosine kinase structure and regulation q

Protein–tyrosine phosphatases such as PTPa displace phosphotyrosine 527 from the Src SH2 domain and mediate its dephosphorylation leading to Src kinase activation.

Src-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites

Biophysical and biochemical studies show that caveolin-1 phosphorylation by Src at Tyr-14, followed by binding of the SH2 domain of activated Src to phospho–Tyr- 14, enhances Src–plasma membrane interaction, providing a mechanism that potentially regulates focal adhesion function.

Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik

It is shown that the observed Src-dependent resistance to cell death relies on Src ability to inhibit the mitochondrial pathway of apoptosis by specifically increasing the degradation rate of the BH3-only protein Bik, which could be a rate-limiting factor for apoptosis induction of tumor cells exhibiting deregulated Erk1/2 signaling.

Mechanisms of Oncogenesis by Retroviruses

Most replication-competent retroviruses cause cancer only after a long latent period, by insertional mutagenesis of the host genome, usually resulting in activation of a cellular proto-oncogene. In
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