The hunting of the Src

@article{Martin2001TheHO,
  title={The hunting of the Src},
  author={G. Steven Martin},
  journal={Nature Reviews Molecular Cell Biology},
  year={2001},
  volume={2},
  pages={467-475}
}
  • G. Martin
  • Published 2001
  • Medicine
  • Nature Reviews Molecular Cell Biology
The non-receptor tyrosine kinase Src is important for many aspects of cell physiology. The viral src gene was the first retroviral oncogene to be identified, and its cellular counterpart was the first proto-oncogene to be discovered in the vertebrate genome. Src has been important, not only as an object of study in itself, but also as an entry point into the molecular genetics of cancer. 
Inhibition of proto-oncogene c-Src tyrosine kinase: toward a new antiarrhythmic strategy?
Cellular-Src (c-Src) encodes a plasma membrane–associated tyrosine protein kinase, which plays a vital role in signaling pathways related to cellular development and carcinogenesis [(1,2)][1]. It wasExpand
Src Family of Protein Tyrosine Kinases
TLDR
The Src family is the subgroup of kinases that share common regulatory mechanisms and possesses overlapping substrate specificity with Src, and transduce signals from adhesion receptors, growth factor receptor, and antigen receptors, and integrate many cell behaviors including proliferation, differentiation, and migration. Expand
6 Regulation of Tyrosine Kinase Signaling by Cbl in Hematopoietic Stem Cells
The first tyrosine kinase (TK) was discovered as the tumor-inducing activity from Rous sarcoma virus, which is now known as v-Src (Rous, 1911). Later studies revealed that the oncogenic properties ofExpand
A renaissance for SRC
  • T. Yeatman
  • Medicine, Biology
  • Nature Reviews Cancer
  • 2004
TLDR
A key role of c-SRC in cancer seems to be to promote invasion and motility, functions that might contribute to tumour progression. Expand
Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses
TLDR
This paper focuses on the roles played by Src and other PTKs in cancer cell-specific behavior, that is, evasion of apoptosis or cell death under stressful extracellular and/or intracellular microenvironments (i.e., hypoxia, anoikis, hypoglycemia, and serum deprivation). Expand
Retroviral oncogenes: a historical primer
TLDR
Key features of all retroviral oncogenes were first identified in src, the oncogene of Rous sarcoma virus, including non-involvement in viral replication, coding for a single protein and cellular origin. Expand
SRC in human carcinogenesis.
  • S. Russello, S. Shore
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual library
  • 2004
TLDR
In a variety of tumor types including those derived from the colon and breast, the Src non-receptor tyrosine kinase is either overexpressed or constitutively active in a large percentage of the tumors. Expand
Src in human carcinogenesis.
TLDR
In a variety of tumor types including those derived from the colon and breast, the Src non-receptor tyrosine kinase is either overexpressed or constitutively active in a large percentage of the tumors. Expand
v-SRC'S hold over actin and cell adhesions
TLDR
Some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src are defined. Expand
Regulation of Src Family Kinases in Human Cancers
TLDR
The mechanisms regulating Src kinase activity in normal and cancer cells are summarized and the status of Src inhibitor development against various types of cancers is discussed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 124 REFERENCES
Crystal structure of the Src family tyrosine kinase Hck
TLDR
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 Å resolution and the conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases. Expand
Regulation, substrates and functions of src.
TLDR
This review focuses on developments in the last 6-7 years, and cites data resulting from the isolation and characterization of SRC mutants, crystallographic studies of the structures of SH2, SH3 and tyrosine kinase domains, biochemical studies of Src kinase activity and binding properties, and the biology of transgenic and knockout mouse strains. Expand
A novel viral oncogene with structural similarity to phospholipase C
TLDR
The previously uncharacterized avian sarcoma virus CT10 is cloned and its genome is sequenced, revealing a protein, p47gag-crk, that has blocks of sequence similarity to the amino-terminal, non-catalytic region of the non-receptor class of tyrosine kinases. Expand
Selected glimpses into the activation and function of Src kinase
TLDR
The history behind the discovery and initial characterization of SRC and the regulatory mechanisms of Src activation, in particular, regulation by modification of the carboxy-terminal regulatory tyrosine by phosphatases and kinases are discussed. Expand
Three-dimensional structure of the tyrosine kinase c-Src
TLDR
The structure of a large fragment of the c-SRC tyrosine kinase, comprising the regulatory and kinase domains and the carboxy-terminal tail, has been determined and shows how appropriate cellular signals, or transforming mutations in v-Src, could break these interactions to produce an open, active kinase. Expand
Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product
TLDR
Data suggest that upon transformation the 34,000-dalton protein is phosphorylated directly as a result of pp60src activity, similar to the major site of phosphorylation in vivo. Expand
Requirement for c-ras proteins during viral oncogene transformation
TLDR
The results show that transformation by three growth factor receptor-like oncogenes depends on c-ras proteins, while transformation by two cytoplasmic onCogenes appears to be independent ofc-ras protein. Expand
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.
TLDR
It is demonstrated that Src can activate STAT signaling pathways and raise the possibility that Stat3 contributes to oncogenesis by Src. Expand
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor.
TLDR
The enlargement of this pocket in autoinhibited Src kinases suggests a route toward the development of inhibitors that are specific for the inactive forms of these proteins. Expand
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates.
TLDR
The development of a protein engineering-based method to identify the direct substrates of the prototypical protein tyrosine kinase v-Src, which controls fibroblast transformation by the Rous sarcoma virus, is described. Expand
...
1
2
3
4
5
...