The hunt for HIV-1 integrase inhibitors.

@article{Lataillade2006TheHF,
  title={The hunt for HIV-1 integrase inhibitors.},
  author={Max Lataillade and Michael J. Kozal},
  journal={AIDS patient care and STDs},
  year={2006},
  volume={20 7},
  pages={489-501}
}
Currently, there are three distinct mechanistic classes of antiretrovirals: inhibitors of the HIV- 1 reverse transcriptase and protease enzymes and inhibitors of HIV entry, including receptor and coreceptor binding and cell fusion. A new drug class that inhibits the HIV-1 integrase enzyme (IN) is in development and may soon be available in the clinic. IN is an attractive drug target because it is essential for a stable and productive HIV-1 infection and there is no mammalian homologue of IN… CONTINUE READING

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