The humanized severe combined immunodeficient mouse as a model for primary human humoral response against HIV1 peptides.

@article{Chargui1995TheHS,
  title={The humanized severe combined immunodeficient mouse as a model for primary human humoral response against HIV1 peptides.},
  author={Jamel Chargui and Danielle Dye and Jonas Blomberg and Claude Desgranges and Jean-louis Touraine},
  journal={Journal of immunological methods},
  year={1995},
  volume={181 1},
  pages={
          91-100
        }
}
Adequate animal models for the study of human immunodeficiency virus (HIV) infection are important for the analysis of specific cellular and humoral immune responses. Humanized severe combined immunodeficiency (SCID) mice can be constructed either by injecting human peripheral blood lymphocytes (hu-PBL-SCID) or by transplanting human fetal tissues--liver, thymus and bone fragments--(SCID-hu) into these mice. Such animals can produce human immunoglobulins and SCID-hu mice exhibit circulating T… CONTINUE READING