The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.

@article{Finzi1987TheHT,
  title={The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.},
  author={E Finzi and Timothy P. Fleming and Oreste Segatto and Carolyn Pennington and Timothy S. Bringman and Rik Derynck and Stuart A. Aaronson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 11},
  pages={3733-7}
}
A peptide secreted by some tumor cells in vitro imparts anchorage-independent growth to normal rat kidney (NRK) cells and has been termed transforming growth factor type alpha (TGF-alpha). To directly investigate the transforming properties of this factor, the human sequence coding for TGF-alpha was placed under the control of either a metallothionein promoter or a retroviral long terminal repeat. These constructs failed to induce morphological transformation upon transfection of NIH 3T3 cells… CONTINUE READING

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