The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis.

@article{Bernt2006TheHT,
  title={The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis.},
  author={Carina Bernt and Timo Vennegeerts and Ulrich H. W. Beuers and Christian Rust},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={340 3},
  pages={800-6}
}
Apoptosis induced by toxic bile acids is thought to contribute to liver injury during cholestasis. The transcription factor AP-1 is involved in the induction of apoptosis depending on stimulus and cell type. It is not known whether the major human toxic bile acid, glycochenodeoxycholic acid (GCDCA), modulates AP-1 in hepatocytes. Our data show that GCDCA (75 microM, 4 h) significantly upregulates cFos and JunB as demonstrated by microarray analysis and real-time PCR in HepG2-Ntcp hepatoma cells… CONTINUE READING

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