The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements.

@article{Hollenberg1995TheHT,
  title={The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements.},
  author={Anthony N. Hollenberg and Tsuyoshi Monden and Timothy R Flynn and M E Boers and Ofer Cohen and Fredric E. Wondisford},
  journal={Molecular endocrinology},
  year={1995},
  volume={9 5},
  pages={540-50}
}
TRH is the principal positive regulator of TSH synthesis and secretion in man. T3 is able to control TRH synthesis through feedback inhibition at the transcriptional level, presumably by binding to its receptor which interacts with one or more negative thyroid hormone response elements (TREs) present within the human TRH promoter. In the present study we have identified the specific negative TREs within the TRH promoter and characterized their ability to interact with thyroid hormone receptors… CONTINUE READING