The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.

Abstract

Thyrotropin is the primary hormone that, via one heptahelical receptor, regulates thyroid cell functions such as secretion, specific gene expression, and growth. In human thyroid, thyrotropin receptor activation leads to stimulation of the adenylyl cyclase and phospholipase C cascades. However, the G proteins involved in thyrotropin receptor action have… (More)

Topics

5 Figures and Tables