The human thyroglobulin gene is over 300 kb long and contains introns of up to 64 kb

  title={The human thyroglobulin gene is over 300 kb long and contains introns of up to 64 kb},
  author={Frank Baas and G. J. van Ommen and H. Bikker and A. C. Arnberg and J. J. de Vijlder},
  journal={Nucleic acids research},
  volume={14 13},
Thyroglobulin (Tg), the precursor of thyroid hormones, is a 660.000 Da dimeric glycoprotein synthesized exclusively in the thyroid gland. We have cloned the human thyroglobulin gene from cosmid and phage libraries and constructed a complete restriction map. The gene encodes an 8.7 kb mRNA, covers at least 300 kb DNA and contains at least 37 exons separated by large introns of up to 64 kb. A striking difference in structure between the 5' and 3' part of the gene suggests that it is composed of… CONTINUE READING

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