The human telomeric protein hTRF1 induces telomere-specific nucleosome mobility

@inproceedings{Pisano2010TheHT,
  title={The human telomeric protein hTRF1 induces telomere-specific nucleosome mobility},
  author={Sabrina Pisano and Daniela Leoni and Alessandra Galati and D. Rhodes and Maria Isabel Savino and Stefano Cacchione},
  booktitle={Nucleic acids research},
  year={2010}
}
Human telomeres consist of thousands of base pairs of double-stranded TTAGGG repeats, organized by histone proteins into tightly spaced nucleosomes. The double-stranded telomeric repeats are also specifically bound by the telomeric proteins hTRF1 and hTRF2, which are essential for telomere length maintenance and for chromosome protection. An unresolved question is what role nucleosomes play in telomere structure and dynamics and how they interact and/or compete with hTRF proteins. Here we show… CONTINUE READING