The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency

@inproceedings{Bigley2011TheHS,
  title={The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency},
  author={Venetia Bigley and Muzlifah Haniffa and Sergei R Doulatov and Xiao-nong Wang and Rachel Emma Dickinson and Naomi McGovern and Laura Jardine and Sarah Pagan and Ian Dimmick and Ignatius Chua and Jonathan P. Wallis and Jim Lordan and Cliff Morgan and Dinakantha Kumararatne and Rainer Doffinger and Mirjam van der Burg and Jacques J. M. van Dongen and Andrew James Cant and John E Dick and Sophie Hambleton and Matthew Collin},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
Congenital or acquired cellular deficiencies in humans have the potential to reveal much about normal hematopoiesis and immune function. We show that a recently described syndrome of monocytopenia, B and NK lymphoid deficiency additionally includes the near absence of dendritic cells. Four subjects showed severe depletion of the peripheral blood HLA-DR(+) lineage(-) compartment, with virtually no CD123(+) or CD11c(+) dendritic cells (DCs) and very few CD14(+) or CD16(+) monocytes. The only… CONTINUE READING