The human sperm epigenome and its potential role in embryonic development.

@article{Carrell2010TheHS,
  title={The human sperm epigenome and its potential role in embryonic development.},
  author={Douglas T. Carrell and Saher Sue Hammoud},
  journal={Molecular human reproduction},
  year={2010},
  volume={16 1},
  pages={37-47}
}
Along with many of the genome-wide transitions in chromatin composition throughout spermatogenesis, epigenetic modifications on histone tails and DNA are continuously modified to ensure stage specific gene expression in the maturing spermatid. Recent findings have suggested that the repertoire of epigenetic modifications in the mature sperm may have a potential role in the developing embryo and alterations in the epigenetic profile have been associated with infertility. These changes include… CONTINUE READING

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