The human specialized DNA polymerases and non-B DNA: vital relationships to preserve genome integrity.

@article{Boyer2013TheHS,
  title={The human specialized DNA polymerases and non-B DNA: vital relationships to preserve genome integrity.},
  author={Anne-Sophie Boyer and Srdana Grgurevic and Christophe Cazaux and Jean-Sebastien Hoffmann},
  journal={Journal of molecular biology},
  year={2013},
  volume={425 23},
  pages={4767-81}
}
In addition to the canonical right-handed double helix, DNA molecule can adopt several other non-B DNA structures. Readily formed in the genome at specific DNA repetitive sequences, these secondary conformations present a distinctive challenge for progression of DNA replication forks. Impeding normal DNA synthesis, cruciforms, hairpins, H DNA, Z DNA and G4 DNA considerably impact the genome stability and in some instances play a causal role in disease development. Along with previously… CONTINUE READING
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