The human side of hypoxia-inducible factor

@article{Smith2008TheHS,
  title={The human side of hypoxia-inducible factor},
  author={Thomas G Smith and Peter A. Robbins and Peter J Ratcliffe},
  journal={British Journal of Haematology},
  year={2008},
  volume={141},
  pages={325 - 334}
}
When humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates that the hypoxia-inducible factor (HIF) family of transcription factors plays a central regulatory role in these homeostatic changes at both the systemic and cellular levels. HIF was discovered through its action as the transcriptional activator of erythropoietin, and has subsequently been found to control intracellular… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 126 CITATIONS, ESTIMATED 54% COVERAGE

High altitude adaptation in Daghestani populations from the Caucasus

  • Human Genetics
  • 2011
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Evidence for a genetic basis for altitude illness: 2010 update.

  • High altitude medicine & biology
  • 2010
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations

  • Averaged 9 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 105 REFERENCES

Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude

P. A. Robbins
  • Respiratory Physiology and Neurobiology,
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Hepcidin and its role in regulating systemic iron metabolism.

  • Hematology. American Society of Hematology. Education Program
  • 2006
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Sonny O. Ang, Hua Chen, +11 authors Josef T. Prchal
  • Nature Genetics
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL