The human serotonin 5‐HT2B receptor: Pharmacological link between 5‐HT2 and 5‐HT1D receptors

  title={The human serotonin 5‐HT2B receptor: Pharmacological link between 5‐HT2 and 5‐HT1D receptors},
  author={D S Choi and Guillaume Birraux and Jean Marie Launay and Luc Maroteaux},
  journal={FEBS Letters},

Developmentally regulated serotonin 5-HT2B receptors

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

These findings confirm the sequence of the human 5‐HT2B receptor and they demonstrate that the receptor has a widespread tissue distribution and suggest that there are differences in ligand affinities between different species homologues of the receptor.

Gene Structure, Expression, and 5-HT2B Receptor Signaling

The complexity of its signaling in relation with its expression, including in various types of cancer cells, is developed and discussed.

Agonist actions of dihydroergotamine at 5‐HT2B and 5‐HT2C receptors and their possible relevance to antimigraine efficacy

Investigations aimed to determine the respective pharmacological profile of DHE and of its major metabolite 8′‐hydroxy‐DHE (8′‐OH‐D HE) at the 5‐ HT2B and 5‐HT2CRs by binding, inositol triphosphate (IP3) or cyclic GMP (cGMP) coupling studies in transfected fibroblasts.

1 New therapeutic opportunities for 5-HT 2 receptor ligands

An overview of the recent pharmacological developments involving the Gq-coupled 5-HT2 receptors subfamily as well as the pathological implications of this receptor subfamily with regard to fibrosis, the central nervous system, cardiovascular disorders and cancer are provided.

5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells.

This report indicates for the first time that 5-HT2B receptors are actively mediating the action of serotonin on embryonic morphogenesis, probably by preventing the differentiation of cranial neural crest cells and myocardial precursor cells.

The 5-HT2-type receptor family



The mouse 5-HT2B receptor: possible involvement in trophic functions of serotonin.

It is demonstrated that the novel serotonin receptor 5-HT2B receptor is functionally expressed before the complete serotoninergic differentiation of 1C11 cells, which could account at least in part for the trophic functions attributed to the 5- HT2-like receptors.

Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.

Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

The affinity of a compound for the 5-HT2F receptor at 37 degrees versus 0 degree was shown to be useful for predicting agonist or antagonist activity, and information is provided about some of the structural requirements for the affinity of certain tryptamines at the 4-HT/1C receptor family.

Serotonin receptors and therapeutics.

This brief review focuses on the pharmacology of 5-HT agonists and antagonists that exhibit, at least partly, clinical relevance.

Further characterization of 5‐hydroxytryptamine receptors (putative 5‐HT2B) in rat stomach fundus longitudinal muscle

It is concluded that despite small differences concerning the enantiomeric selectivity and affinity of rauwolscine and yohimbine, the close pharmacological identity of 5‐HT receptors in rat stomach fundus and the recently cloned 5‐ HT2B receptor is maintained.

The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked.

Molecular biology of 5-HT receptors.

  • P. Hartig
  • Biology, Chemistry
    Trends in pharmacological sciences
  • 1989

A subfamily of 5-HT1D receptor genes.